Jagged 2

Human Jagged 2 is a member of the Delta-Serrate-Lag-2 (DSL) family of ligands. This family activates LIN12/Notch proteins and thereby regulates cell fate determination during development. Notch signaling is an ancient signaling system that plays important roles in cell fate decision and stem cell maintenance in embryonic and postnatal tissues. In mammals, there are four transmembrane Notch receptors, Notch-1, Notch-2, Notch-3, and Notch-4, and five ligands for the receptors, Jagged-1 and Jagged-2, belonging to the serrate family, and Delta-1, Delta-3, and Delta-4, belonging to the Delta family.